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    Exchange 2010 – File-Level Scanning Exclusions


    Detailed list from Microsoft here

    Folder Exclusions:
    C:\Program Files\Microsoft\Exchange Server\V14\Mailbox
    C:\Program Files\Microsoft\Exchange Server\V14\Mailbox\MDBTEMP
    C:\Program Files\Microsoft\Exchange Server\V14\ExchangeOAB
    C:\Program Files\Microsoft\Exchange Server\V14\ClientAccess
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\data\Queue
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\data\IpFilter
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Logs
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\Queue
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\IpFilter
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\Adam
    C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\SenderReputation
    C:\Program Files\Microsoft\Exchange Server\V14\Working\OleConvertor
    C:\Program Files\Microsoft\Exchange Server\V14\GroupMetrics
    C:\Program Files\Microsoft\Exchange Server\V14\Logging
    C:\Program Files\Microsoft\Exchange Server\V14\Logging\POP3
    C:\Program Files\Microsoft\Exchange Server\V14\Logging\IMAP4
    C:\Program Files\Microsoft\Exchange Server\V14\Working\OleConvertor
    C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\grammars
    C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\Prompts
    C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\voicemail
    C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\temp
    C:\Windows\System32\inetsrv
    C:\Windows\Cluster
    C:\witness
    C:\inetpub\temp\IIS Temporary Compressed Files
    C:\Windows\System32\inetsrv
    C:\inetpub\logs\LogFiles

    Processes Exclusions:
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeADTopologyService.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\ExFBA.exe
    C:\Program Files\Microsoft\Exchange Server\V14\bin\store.exe
    C:\Program Files\Microsoft\Exchange Server\V14\bin\mad.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\msftesql.exe
    C:\Program Files\Microsoft\Exchange Server\V14\bin\Microsoft.Exchange.AddressBook.Service.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\Microsoft.Exchange.AntispamUpdateSvc.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\Microsoft.Exchange.EdgeSyncSvc.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeFDS.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailboxAssistants.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailboxReplication.exe
    C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailSubmission.exe
    C:\Program Files\Microsoft\Exchange Server\V14\bin\Microsoft.Exchange.ProtectedServiceHost.exe

    Cdb.exe
    Microsoft.Exchange.Search.Exsearch.exe
    Cidaemon.exe
    Microsoft.Exchange.Servicehost.exe
    Clussvc.exe
    MSExchangeADTopologyService.exe
    Dsamain.exe
    MSExchangeFDS.exe
    EdgeCredentialSvc.exe
    MSExchangeMailboxAssistants.exe
    EdgeTransport.exe
    MSExchangeMailboxReplication.exe
    MSExchangeMailSubmission.exe
    GalGrammarGenerator.exe
    MSExchangeRepl.exe
    Inetinfo.exe
    MSExchangeTransport.exe
    MSExchangeTransportLogSearch.exe
    Microsoft.Exchange.AddressBook.Service.exe
    MSExchangeThrottling.exe
    Microsoft.Exchange.AntispamUpdateSvc.exe
    Msftefd.exe
    Microsoft.Exchange.ContentFilter.Wrapper.exe
    Msftesql.exe
    Microsoft.Exchange.EdgeSyncSvc.exe
    OleConverter.exe
    Microsoft.Exchange.Imap4.exe
    Powershell.exe
    Microsoft.Exchange.Imap4service.exe
    SESWorker.exe
    Microsoft.Exchange.Infoworker.Assistants.exe
    SpeechService.exe
    Microsoft.Exchange.Monitoring.exe
    Microsoft.Exchange.Pop3.exe
    TranscodingService.exe
    Microsoft.Exchange.Pop3service.exe
    UmService.exe
    UmWorkerProcess.exe
    Microsoft.Exchange.RPCClientAccess.Service.exe
    W3wp.exe