Exchange 2010 – File-Level Scanning Exclusions
Detailed list from Microsoft here
Folder Exclusions:
C:\Program Files\Microsoft\Exchange Server\V14\Mailbox
C:\Program Files\Microsoft\Exchange Server\V14\Mailbox\MDBTEMP
C:\Program Files\Microsoft\Exchange Server\V14\ExchangeOAB
C:\Program Files\Microsoft\Exchange Server\V14\ClientAccess
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\data\Queue
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\data\IpFilter
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Logs
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\Queue
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\IpFilter
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\Adam
C:\Program Files\Microsoft\Exchange Server\V14\TransportRoles\Data\SenderReputation
C:\Program Files\Microsoft\Exchange Server\V14\Working\OleConvertor
C:\Program Files\Microsoft\Exchange Server\V14\GroupMetrics
C:\Program Files\Microsoft\Exchange Server\V14\Logging
C:\Program Files\Microsoft\Exchange Server\V14\Logging\POP3
C:\Program Files\Microsoft\Exchange Server\V14\Logging\IMAP4
C:\Program Files\Microsoft\Exchange Server\V14\Working\OleConvertor
C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\grammars
C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\Prompts
C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\voicemail
C:\Program Files\Microsoft\Exchange Server\V14\UnifiedMessaging\temp
C:\Windows\System32\inetsrv
C:\Windows\Cluster
C:\witness
C:\inetpub\temp\IIS Temporary Compressed Files
C:\Windows\System32\inetsrv
C:\inetpub\logs\LogFiles
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Processes Exclusions:
C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeADTopologyService.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\ExFBA.exe
C:\Program Files\Microsoft\Exchange Server\V14\bin\store.exe
C:\Program Files\Microsoft\Exchange Server\V14\bin\mad.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\msftesql.exe
C:\Program Files\Microsoft\Exchange Server\V14\bin\Microsoft.Exchange.AddressBook.Service.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\Microsoft.Exchange.AntispamUpdateSvc.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\Microsoft.Exchange.EdgeSyncSvc.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeFDS.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailboxAssistants.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailboxReplication.exe
C:\Program Files\Microsoft\Exchange Server\V14\Bin\MSExchangeMailSubmission.exe
C:\Program Files\Microsoft\Exchange Server\V14\bin\Microsoft.Exchange.ProtectedServiceHost.exe
Cdb.exe
Microsoft.Exchange.Search.Exsearch.exe
Cidaemon.exe
Microsoft.Exchange.Servicehost.exe
Clussvc.exe
MSExchangeADTopologyService.exe
Dsamain.exe
MSExchangeFDS.exe
EdgeCredentialSvc.exe
MSExchangeMailboxAssistants.exe
EdgeTransport.exe
MSExchangeMailboxReplication.exe
MSExchangeMailSubmission.exe
GalGrammarGenerator.exe
MSExchangeRepl.exe
Inetinfo.exe
MSExchangeTransport.exe
MSExchangeTransportLogSearch.exe
Microsoft.Exchange.AddressBook.Service.exe
MSExchangeThrottling.exe
Microsoft.Exchange.AntispamUpdateSvc.exe
Msftefd.exe
Microsoft.Exchange.ContentFilter.Wrapper.exe
Msftesql.exe
Microsoft.Exchange.EdgeSyncSvc.exe
OleConverter.exe
Microsoft.Exchange.Imap4.exe
Powershell.exe
Microsoft.Exchange.Imap4service.exe
SESWorker.exe
Microsoft.Exchange.Infoworker.Assistants.exe
SpeechService.exe
Microsoft.Exchange.Monitoring.exe
Microsoft.Exchange.Pop3.exe
TranscodingService.exe
Microsoft.Exchange.Pop3service.exe
UmService.exe
UmWorkerProcess.exe
Microsoft.Exchange.RPCClientAccess.Service.exe
W3wp.exe